This second National HIV Prevention Policy 2019 for the Kingdom of Eswatini demonstrates the milestones achieved thus far in the country's HIV and AIDS response. The country is geared towards ending AIDS as a public health threat by 2022. The policy provides for an enabling environment to intensify the prevention response implementation towards this goal. It emphasises the need and focus towards the over 800 000 emaSwati who are HIV negative while treating those living with HIV to prolong their lives. The policy development process took to account the state of the epidemic to date and evolved its guidance from programatic issues to more policy and systems issues that will facilitate scaling up prevention interventions. The policy is human-centred and focuses on the needs of the local communities using different tested prevention technologies.